The U.S. Patent Office awarded Dr. Mythily Srinivasan, associate professor, Oral Pathology, Medicine, and Radiology, her third patent on Dec. 15, 2020.
Patent #10,864,244, titled “Peptides and methods for treatment of neurodegenerative diseases ,” covers PGA, second-generation peptide analogs intended for suppressing chronic inflammation in neurodegenerative diseases, such as Alzheimer's, Parkinson's, multiple sclerosis, and amyotrophic lateral sclerosis. This patent is an extension of Dr. Srinivasan’s previous inventions in the field of immunomodulatory therapeutics, which are substances that help regulate the immune system.
IUSD Dean Carol Anne Murdoch-Kinch said, “Patents developed by our researchers at IUSD serve to propel the scientific discovery and innovation needed to advance oral and systemic health for future generations.”
“I want to thank Dr. Joseph Trebley, founder, Monon Ventures, who initially recognized the value of PGA, advised to protect it, and encouraged us to apply for small business grants,” Dr. Srinivasan said. “The IU Innovation and Commercialization Office has been extremely helpful in all steps of the process, for which I’m very grateful.”
Drs. Debomoy Lahiri and Adrian Oblak, IU School of Medicine, and Dr. Chandler Walker, assistant professor, IUSD Biomedical Sciences and Comprehensive Care, are part of the phase II subcontract to advance preclinical development of PGA at IUPUI.